Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
about
Stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic loadCaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity.Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.Chasing cardiac physiology and pathology down the CaMKII cascadeThe couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle.Essential Role of Calmodulin in RyR Inhibition by Dantrolene.Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?Bioactive nanoparticles improve calcium handling in failing cardiac myocytes.Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.β-adrenergic stimulation increases the intra-SR Ca termination threshold for spontaneous Ca waves in cardiac myocytes.Dantrolene: from better bacon to a treatment for ventricular fibrillation.Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Structural and functional interactions within ryanodine receptor.Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Emerging pathways driving early synaptic pathology in Alzheimer's disease.CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic β-Adrenergic Receptor Activation.Inositol-1,4,5-trisphosphate induced Ca2+ release and excitation-contraction coupling in atrial myocytes from normal and failing hearts.Dyssynchronous calcium removal in heart failure-induced atrial remodeling.Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.Ca2+ leak-What is it? Why should we care? Can it be managed?Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.Simulation of the effects of moderate stimulation/inhibition of the β1-adrenergic signaling system and its components in mouse ventricular myocytes.Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.Dantrolene suppresses ventricular ectopy and arrhythmogenicity with acute myocardial infarction in a langendorff-perfused pacing-induced heart failure rabbit model.
P2860
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P2860
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@ast
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@en
type
label
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@ast
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@en
prefLabel
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@ast
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@en
P2093
P2860
P1476
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
@en
P2093
Joshua T Maxwell
Lothar A Blatter
Timothy L Domeier
P2860
P304
P356
10.1152/AJPHEART.00936.2011
P577
2011-12-16T00:00:00Z