Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
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Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomesPotential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and MethamphetamineAlzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicityConjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancerThe σ2 receptor: a novel protein for the imaging and treatment of cancer.Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy.Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor ActivitySigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.Effects of the lysosomal destabilizing drug siramesine on glioblastoma in vitro and in vivoSigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma.Tetrahydroprotoberberine alkaloids with dopamine and σ receptor affinity.Sigma receptors [σRs]: biology in normal and diseased statesDevelopment of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors.The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target.Functional assays to define agonists and antagonists of the sigma-2 receptor.Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016).Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: hints for collateral sensitivity.Sigma1 Pharmacology in the Context of Cancer.Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma.Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors.Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle.Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity.
P2860
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P2860
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
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2012年论文
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name
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@ast
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@en
type
label
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@ast
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@en
prefLabel
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@ast
Sigma-2 ligands induce tumour cell death by multiple signalling pathways.
@en
P2093
P2860
P356
P1476
Sigma-2 ligands induce tumour cell death by multiple signalling pathways
@en
P2093
J Rothfuss
R Hotchkiss
S Vangveravong
P2860
P2888
P304
P356
10.1038/BJC.2011.602
P407
P50
P577
2012-01-17T00:00:00Z