Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
about
Toxic cardenolides: chemical ecology and coevolution of specialized plant-herbivore interactionsIsolation of a multispecific organic anion and cardiac glycoside transporter from rat brainDeveloping Enhanced Blood-Brain Barrier Permeability Models: Integrating External Bio-Assay Data in QSAR ModelingSecretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue.Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain.Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposureABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) geneExpression and function of multidrug resistance transporters at the blood-brain barriers.Inhibition of P-glycoprotein function by procyanidine on blood-brain barrier.Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation.Principles in pharmacogenetics.Polymorphisms in the ABC drug transporter gene MDR1.Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo.Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.Pharmacokinetic interaction between itraconazole and ceftriaxone in Yucatan miniature pigs.Importance of P-glycoprotein for drug disposition in humans.The effects of fruit juices on drug disposition: a new model for drug interactions.P-glycoprotein-based drug-drug interactions: preclinical methods and relevance to clinical observations.MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.Ethnicity-related polymorphisms and haplotypes in the human ABCB1 geneThe ABC transporters MDR1 and MRP2: multiple functions in disposition of xenobiotics and drug resistance.Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineNormal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins.P-glycoprotein structure and evolutionary homologies.Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein.Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in MiceDefining targets for investigating the pharmacogenomics of adverse drug reactions to antifungal agents.Investigation of the influence of FcRn on the distribution of IgG to the brainTumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies.Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges.Loss of orally administered drugs in GI tract.Suitability of digoxin as a P-glycoprotein probe: implications of other transporters on sensitivity and specificity.Nano-enabled delivery systems across the blood-brain barrier.Vitamin E-drug interactions: molecular basis and clinical relevance.Clinical pharmacology profile of boceprevir, a hepatitis C virus NS3 protease inhibitor: focus on drug-drug interactions.Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature.No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients.
P2860
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P2860
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@ast
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@en
type
label
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@ast
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@en
prefLabel
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@ast
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@en
P2093
P2860
P1476
Substantial excretion of digox ...... n by the mdr 1a P-glycoprotein
@en
P2093
Beijnen JH
Schinkel AH
Wagenaar E
van Asperen J
P2860
P304
P356
10.1111/J.1476-5381.1996.TB15775.X
P407
P577
1996-11-01T00:00:00Z