High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. - Wikidata - awgldk - TriplyDB

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

http://www.wikidata.org/entity/Q35887278

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Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol Antioxidants in Translational Medicine Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.Blinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants Cell-based high-throughput screens for the discovery of chemotherapeutic agents.ATM/CHK/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene.A Palladium Catalyst System for the Efficient Cross-Coupling Reaction of Aryl Bromides and Chlorides with Phenylboronic Acid: Synthesis and Biological Activity Evaluation.Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.Anti-Bladder-Tumor Effect of Baicalein from Scutellaria baicalensis Georgi and Its Application In Vivo A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis.Improving the human hazard characterization of chemicals: a Tox21 update Dietary supplementation with a high dose of daidzein enhances the antioxidant capacity in swine muscle but experts pro-oxidant function in liver and fat tissues.A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells.Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity.Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells.Baicalein has protective effects on the 17β-estradiol-induced transformation of breast epithelial cells.Polyphenols as active ingredients for cosmetic products.In Vitro DNA-Binding, Anti-Oxidant and Anticancer Activity of Indole-2-Carboxylic Acid Dinuclear Copper(II) Complexes.Evaluation of four human cell lines with distinct biotransformation properties for genotoxic screening.Gallic acid exerts a protective or an anti-proliferative effect on glioma T98G cells via dose-dependent epigenetic regulation mediated by miRNAs.Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells.Methanolic extracts of Solieria robusta inhibits proliferation of oral cancer Ca9-22 cells via apoptosis and oxidative stress.Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells.Ataxia-telangiectasia mutated kinase-mediated upregulation of NKG2D ligands on leukemia cells by resveratrol results in enhanced natural killer cell susceptibility.Modulation of bacterial ghosts--induced nitric oxide production in macrophages by bacterial ghost-delivered resveratrol.Organ and tissue-dependent effect of resveratrol and exercise on antioxidant defenses of old mice.Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential.Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidants.Soy isoflavones have antimutagenic activity on DNA damage induced by the antileishmanial Glucantime (meglumine antimoniate).Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals.Reply to Kojo: Mechanisms of antioxidant-induced DNA damage.Short-lived phenoxyl radicals formed from green-tea polyphenols and highly reactive oxygen species: an investigation by time-resolved EPR spectroscopy.Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice.Next generation high throughput DNA damage detection platform for genotoxic compound screening.The Impact of Novel Assessment Methodologies in Toxicology on Green Chemistry and Chemical Alternatives.Two CYP82D Enzymes Function as Flavone Hydroxylases in the Biosynthesis of Root-Specific 4'-Deoxyflavones in Scutellaria baicalensis.Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.Synthesis of multifunctional bioresponsive polymers for the management of chronic wounds.

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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

http://www.wikidata.org/entity/Q35887278

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name

High-throughput genotoxicity a ...... amage response and cell death.

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High-throughput genotoxicity a ...... amage response and cell death.

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High-throughput genotoxicity a ...... amage response and cell death.

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High-throughput genotoxicity a ...... amage response and cell death.

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Proceedings of the National Academy of Sciences of the United States of America

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High-throughput genotoxicity a ...... damage response and cell death

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Jennifer T Fox

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Kyungjae Myung

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Menghang Xia

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Nedelina Teneva

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Raymond R Tice

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Ruili Huang

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Srilatha Sakamuru

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P2860

hRAD30 mutations in the variant form of xeroderma pigmentosum

Predisposition to cancer caused by genetic and functional defects of mammalian Atad5

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta.

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

Genotoxicity of phytoestrogens

Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Compound cytotoxicity profiling using quantitative high-throughput screening.

Characterization of chemical libraries for luciferase inhibitory activity.

Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.

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Steven O Simmons

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