Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie in hamsters and changed their pathogenic features.
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Exploring the risks of a putative transmission of BSE to new speciesRe-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c.MiRNA expression profiles in the brains of mice infected with scrapie agents 139A, ME7 and S15.Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages.Treatment of SMB-S15 Cells with Resveratrol Efficiently Removes the PrP(Sc) Accumulation In Vitro and Prion Infectivity In Vivo.Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of Sirt1.Apparent reduction of ADAM10 in scrapie-infected cultured cells and in the brains of scrapie-infected rodents.Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.Significant reduction of the GLUT3 level, but not GLUT1 level, was observed in the brain tissues of several scrapie experimental animals and scrapie-infected cell lines.Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents.Abortive cell cycle events in the brains of scrapie-infected hamsters with remarkable decreases of PLK3/Cdc25C and increases of PLK1/cyclin B1.PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn.The Brain NO Levels and NOS Activities Ascended in the Early and Middle Stages and Descended in the Terminal Stage in Scrapie-Infected Animal Models.Remarkable impairment of Wnt/β-catenin signaling in the brains of the mice infected with scrapie agents.Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions.Increases of Galectin-1 and its S-nitrosylated form in the Brain Tissues of Scrapie-Infected Rodent Models and Human Prion Diseases.The Levels of Tau Isoforms Containing Exon-2 and Exon-10 Segments Increased in the Cerebrospinal Fluids of the Patients with Sporadic Creutzfeldt-Jakob Disease.Remarkable Activation of the Complement System and Aberrant Neuronal Localization of the Membrane Attack Complex in the Brain Tissues of Scrapie-Infected Rodents.Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection.Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.
P2860
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P2860
Mouse-adapted scrapie strains 139A and ME7 overcome species barrier to induce experimental scrapie in hamsters and changed their pathogenic features.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@ast
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@en
type
label
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@ast
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@en
prefLabel
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@ast
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@en
P2093
P2860
P356
P1433
P1476
Mouse-adapted scrapie strains ...... ged their pathogenic features.
@en
P2093
Bao-Yun Zhang
Hui-Ying Jiang
Xiao-Ping Dong
P2860
P356
10.1186/1743-422X-9-63
P577
2012-03-09T00:00:00Z