Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
about
Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 diseaseAn orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cellsHIV type I envelope determinants for use of the CCR2b, CCR3, STRL33, and APJ coreceptorsCellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120Evolutionary reversals during viral adaptation to alternating hostsStructure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc ComplexStructure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodySensitivity to a nonpeptidic compound (RPR103611) blocking human immunodeficiency virus type 1 Env-mediated fusion depends on sequence and accessibility of the gp41 loop regionSensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptorThe influence of N-linked glycans on the molecular dynamics of the HIV-1 gp120 V3 loop.HIV-1 envelope subregion length variation during disease progressionProbing sequence variation in the receptor-targeting domain of feline leukemia virus envelope proteins with peptide display libraries.Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.Net positive charge of HIV-1 CRF01_AE V3 sequence regulates viral sensitivity to humoral immunity.Different tempo and anatomic location of dual-tropic and X4 virus emergence in a model of R5 simian-human immunodeficiency virus infection.Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants.Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family.V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Kinetic factors control efficiencies of cell entry, efficacies of entry inhibitors, and mechanisms of adaptation of human immunodeficiency virusVariants of human immunodeficiency virus type 1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120, including loss of a functional N-glycanMultiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates.The cell tropism of human immunodeficiency virus type 1 determines the kinetics of plasma viremia in SCID mice reconstituted with human peripheral blood leukocytes.Determinants of entry cofactor utilization and tropism in a dualtropic human immunodeficiency virus type 1 primary isolate.Rabbit cells expressing human CD4 and human CCR5 are highly permissive for human immunodeficiency virus type 1 infectionNeuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patientsHuman immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissueSelective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopesCytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1Association of structural changes in the V2 and V3 loops of the gp120 envelope glycoprotein with acquisition of neutralization resistance in a simian-human immunodeficiency virus passaged in vivo.Role of naturally occurring basic amino acid substitutions in the human immunodeficiency virus type 1 subtype E envelope V3 loop on viral coreceptor usage and cell tropismCharacterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants.Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolatesAnalysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization.Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy.Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.Antigenic variation within the CD4 binding site of human immunodeficiency virus type 1 gp120: effects on chemokine receptor utilization.N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropismCD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain.Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants
P2860
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P2860
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Selective employment of chemok ...... ds within the envelope V3 loop
@ast
Selective employment of chemok ...... ds within the envelope V3 loop
@en
type
label
Selective employment of chemok ...... ds within the envelope V3 loop
@ast
Selective employment of chemok ...... ds within the envelope V3 loop
@en
prefLabel
Selective employment of chemok ...... ds within the envelope V3 loop
@ast
Selective employment of chemok ...... ds within the envelope V3 loop
@en
P2093
P2860
P1433
P1476
Selective employment of chemok ...... ds within the envelope V3 loop
@en
P2093
B Chesebro
M A Goldsmith
R E Atchison
P2860
P304
P407
P577
1997-09-01T00:00:00Z