Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates
about
Molecular recognition of CXCR4 by a dual tropic HIV-1 gp120 V3 loopInfection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1.Structure modeling of all identified G protein-coupled receptors in the human genomeUnique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors.Fine definition of the CXCR4-binding region on the V3 loop of feline immunodeficiency virus surface glycoprotein.Anti-CXCR4 monoclonal antibodies recognizing overlapping epitopes differ significantly in their ability to inhibit entry of human immunodeficiency virus type 1.N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates.Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5.Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domainsThird extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 bindingIdentification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.NMR metabolomics of MTLn3E breast cancer cells identifies a role for CXCR4 in lipid and choline regulation.A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry.Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors.Regulation of CXCR4 signaling.Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitorsSpecific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection.Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transductionCritical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues.Biology and clinical relevance of chemokines and chemokine receptors CXCR4 and CCR5 in human diseases.Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.Unique monoclonal antibody recognizing the third extracellular loop of CXCR4 induces lymphocyte agglutination and enhances human immunodeficiency virus type 1-mediated syncytium formation and productive infection.Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses.Cooperation of the V1/V2 and V3 domains of human immunodeficiency virus type 1 gp120 for interaction with the CXCR4 receptor.Evidence for common structural determinants of human immunodeficiency virus type 1 coreceptor activity provided through functional analysis of CCR5/CXCR4 chimeric coreceptorsCCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates.Variability in the human immunodeficiency virus type 1 gp120 Env protein linked to phenotype-associated changes in the V3 loop.Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies.The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment.GPCR Conformations: Implications for Rational Drug Design.
P2860
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P2860
Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates
description
1999 nî lūn-bûn
@nan
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@ast
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@en
type
label
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@ast
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@en
prefLabel
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@ast
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@en
P2093
P2860
P1433
P1476
Mutagenesis of CXCR4 identifie ...... eptor activity for R5 isolates
@en
P2093
C C Broder
D J Chabot
G V Quinnan
P2860
P304
P577
1999-08-01T00:00:00Z