The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
about
Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Generation and repair of AID-initiated DNA lesions in B lymphocytes.MutLα heterodimers modify the molecular phenotype of Friedreich ataxia.Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerasesThe dual nature of mismatch repair as antimutator and mutator: for better or for worse.Downregulation of FOXP1 is required during germinal center B-cell function.Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences.
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P2860
The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination
description
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name
The ATPase activity of MLH1 is ...... ing class switch recombination
@ast
The ATPase activity of MLH1 is ...... ing class switch recombination
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type
label
The ATPase activity of MLH1 is ...... ing class switch recombination
@ast
The ATPase activity of MLH1 is ...... ing class switch recombination
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prefLabel
The ATPase activity of MLH1 is ...... ing class switch recombination
@ast
The ATPase activity of MLH1 is ...... ing class switch recombination
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P2093
P2860
P356
P1476
The ATPase activity of MLH1 is ...... ing class switch recombination
@en
P2093
Chunfang Zhao
Elena Avdievich
Johanna M M van Oers
Matthew D Scharff
Winfried Edelmann
P2860
P304
P356
10.1084/JEM.20111531
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P577
2012-03-26T00:00:00Z