Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. - Wikidata - awgldk - TriplyDB

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

http://www.wikidata.org/entity/Q35894389

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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis Transporting mitochondria in neurons Role of Intermediate Filaments in Vesicular Traffic Dysregulated axonal RNA translation in amyotrophic lateral sclerosis Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad A comprehensive review of amyotrophic lateral sclerosis Molecular motor proteins and amyotrophic lateral sclerosis Charcot-Marie-Tooth disease and intracellular traffic Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis Neuroprotection of antioxidant enzymes against transient global cerebral ischemia in gerbils Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo A Case for Microtubule Vulnerability in Amyotrophic Lateral Sclerosis: Altered Dynamics During Disease The complex molecular biology of amyotrophic lateral sclerosis (ALS)Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS)Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.Deficits in axonal transport precede ALS symptoms in vivo.Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis.Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models.Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.

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Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.

http://www.wikidata.org/entity/Q35894389

description

2007 nî lūn-bûn

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Familial amyotrophic lateral s ...... e axonal mitochondria content.

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Familial amyotrophic lateral s ...... e axonal mitochondria content.

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Familial amyotrophic lateral s ...... e axonal mitochondria content.

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Familial amyotrophic lateral s ...... e axonal mitochondria content.

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Human Molecular Genetics

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Familial amyotrophic lateral s ...... e axonal mitochondria content.

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Anna L Chapman

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Catherine Manser

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Christopher C J Miller

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Elizabeth L Tudor

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Janet Brownlees

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Maria E Tennant

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Steven Ackerley

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P2860

The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

ALS: a disease of motor neurons and their nonneuronal neighbors

Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons

The genetics of axonal transport and axonal transport disorders

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

Axonal transport of neurofilaments in normal and disease states.

Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials.

Molecular and cellular pathways of neurodegeneration in motor neurone disease

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2720-2728

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10.1093/HMG/DDM226

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22

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16

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Declan McLoughlin

Andrew Grierson

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2007-08-28T00:00:00Z

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6114348

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17725983

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amyotrophic lateral sclerosis

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4516806

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