Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus.
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Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1Live attenuated Rev-independent Nef¯SIV enhances acquisition of heterologous SIVsmE660 in acutely vaccinated rhesus macaquesCharacterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profilingRectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef VaccinationCD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protectionADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challengeDetection of Diverse Hepatitis C Virus (HCV)-Specific Cytotoxic T Lymphocytes in Peripheral Blood of Infected Persons by Screening for Responses to All Translated Proteins of HCVInhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1Characterization of T-cell responses in macaques immunized with a single dose of HIV DNA vaccineInhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1.Inhibition of simian immunodeficiency virus (SIV) replication by CD8(+) T lymphocytes from macaques immunized with live attenuated SIVTemporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus.Pathogenic simian/human immunodeficiency virus SHIV(KU) inoculated into immunized macaques caused infection, but virus burdens progressively declined with time.Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virionsSuppression of acute viremia by short-term postexposure prophylaxis of simian/human immunodeficiency virus SHIV-RT-infected monkeys with a novel reverse transcriptase inhibitor (GW420867) allows for development of potent antiviral immune responses rEnhanced binding of antibodies to neutralization epitopes following thermal and chemical inactivation of human immunodeficiency virus type 1.Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus.Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection.Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.Protection by live, attenuated simian immunodeficiency virus against heterologous challenge.In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques.Polymorphisms in HLA class I genes associated with both favorable prognosis of human immunodeficiency virus (HIV) type 1 infection and positive cytotoxic T-lymphocyte responses to ALVAC-HIV recombinant canarypox vaccines.Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS modelCD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virusEarly potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques.Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge.Transcriptional profiling of peripheral CD8+T cell responses to SIVΔnef and SIVmac251 challenge reveals a link between protective immunity and induction of systemic immunoregulatory mechanisms.Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus.Viral phenotypes and antibody responses in long-term survivors infected with attenuated human immunodeficiency virus type 1 containing deletions in the nef and long terminal repeat regions.Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV InfectionInduction of a virus-specific effector-memory CD4+ T cell response by attenuated SIV infection.Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccineDramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail.Effects of in vivo CD8(+) T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine.Immunization with live attenuated simian immunodeficiency virus induces strong type 1 T helper responses and beta-chemokine productionMacaques vaccinated with live-attenuated SIV control replication of heterologous virus.DNA-MVA vaccine protection after X4 SHIV challenge in macaques correlates with day-of-challenge antiviral CD4+ cell-mediated immunity levels and postchallenge preservation of CD4+ T cell memory.
P2860
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P2860
Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@ast
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@en
type
label
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@ast
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@en
prefLabel
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@ast
Induction of vigorous cytotoxi ...... simian immunodeficiency virus.
@en
P2093
P2860
P921
P1433
P1476
Induction of vigorous cytotoxi ...... simian immunodeficiency virus
@en
P2093
M J Mulligan
R C Desrosiers
R L Glickman
R P Johnson
P2860
P304
P407
P577
1997-10-01T00:00:00Z