MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. - Wikidata - awgldk - TriplyDB

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

http://www.wikidata.org/entity/Q35898171

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SYK is a critical regulator of FLT3 in acute myeloid leukemia Acute lymphoblastic leukaemia New and emerging prognostic and predictive genetic biomarkers in B-cell precursor acute lymphoblastic leukemia Epigenetic regulators and their impact on therapy in acute myeloid leukemia Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance The complexity of epigenetic diseases Pediatric AML: From Biology to Clinical Management KATs in cancer: functions and therapies Mechanisms of epigenetic regulation of leukemia onset and progression Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention Concise review: Leukemia stem cells in personalized medicine The next steps in next-gen sequencing of cancer genomes Cancer epigenetics drug discovery and development: the challenge of hitting the mark Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer Cell-cycle dependent expression of a translocation-mediated fusion oncogene mediates checkpoint adaptation in rhabdomyosarcoma Potent inhibition of DOT1L as treatment of MLL-fusion leukemia Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L Emerging concepts of epigenetic dysregulation in hematological malignancies Epigenetics in Cancer: A Hematological Perspective A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia LSD1 inhibition: a therapeutic strategy in cancer?A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis Associations between Blood and Urine Arsenic Concentrations and Global Levels of Post-Translational Histone Modifications in Bangladeshi Men and Women Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)Future prospects of therapeutic clinical trials in acute myeloid leukemia.Biomarkers of genome instability and cancer epigenetics.Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach Disordered epigenetic regulation in MLL-related leukemia.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.Large-scale quality analysis of published ChIP-seq data.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center.ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia.

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P2860

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

http://www.wikidata.org/entity/Q35898171

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

@ast

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

@en

type

label

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

@ast

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

@en

prefLabel

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

@ast

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

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J.CCR.2011.06.010

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P1476

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L

@en

P2093

Amanda Daigle

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Amit U Sinha

http://www.w3.org/2001/XMLSchema#string

Joerg Faber

http://www.w3.org/2001/XMLSchema#string

Lars Bullinger

http://www.w3.org/2001/XMLSchema#string

Nan Zhu

http://www.w3.org/2001/XMLSchema#string

Natalie Punt

http://www.w3.org/2001/XMLSchema#string

Roy M Pollock

http://www.w3.org/2001/XMLSchema#string

Scott A Armstrong

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Sridhar Vempati

http://www.w3.org/2001/XMLSchema#string

Victoria M Richon

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P2860

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

DNMT3A Mutations in Acute Myeloid Leukemia

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

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66-78

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10.1016/J.CCR.2011.06.010

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1

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20

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Kathrin M. Bernt

Andrei Krivtsov

Kathrin M Bernt

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2011-07-01T00:00:00Z

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51479221

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