Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
about
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)HIV-1 Env C2-V4 diversification in a slow-progressor infant reveals a flat but rugged fitness landscapeA dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression.The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activitiesDecreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1.Genotypic testing for human immunodeficiency virus type 1 drug resistance.Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infectionVirulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus.Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture.Fluorescent dye terminator sequencing methods for quantitative determination of replication fitness of human immunodeficiency virus type 1 containing the codon 74 and 184 mutations in reverse transcriptase.Replication-independent expression of anti-apoptosis marker genes in human peripheral blood mononuclear cells infected with the wild-type HIV-1 and reverse transcriptase variantsVicriviroc resistance decay and relative replicative fitness in HIV-1 clinical isolates under sequential drug selection pressures.Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations.A sensitive real-time PCR based assay to estimate the impact of amino acid substitutions on the competitive replication fitness of human immunodeficiency virus type 1 in cell cultureClinical significance of human immunodeficiency virus type 1 replication fitness.Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant virusesHydroxyurea enhances the activities of didanosine, 9-[2-(phosphonylmethoxy)ethyl]adenine, and 9-[2-(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates.Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progressionReplicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication.Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity.Human immunodeficiency virus type 1: resistance to nucleoside analogues and replicative capacity in primary human macrophages.Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase.Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues.Pairwise growth competition assay for determining the replication fitness of human immunodeficiency viruses.The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.Impact of human immunodeficiency virus type 1 reverse transcriptase inhibitor drug resistance mutation interactions on phenotypic susceptibility.
P2860
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P2860
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Attenuated replication of huma ...... everse transcriptase mutation.
@ast
Attenuated replication of huma ...... everse transcriptase mutation.
@en
type
label
Attenuated replication of huma ...... everse transcriptase mutation.
@ast
Attenuated replication of huma ...... everse transcriptase mutation.
@en
prefLabel
Attenuated replication of huma ...... everse transcriptase mutation.
@ast
Attenuated replication of huma ...... everse transcriptase mutation.
@en
P2860
P1433
P1476
Attenuated replication of huma ...... reverse transcriptase mutation
@en
P2093
C S Crumpacker
P L Sharma
P2860
P304
P407
P577
1997-11-01T00:00:00Z