An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence
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Theiler's virus infection: a model for multiple sclerosisAlphavirus-specific cytotoxic T lymphocytes recognize a cross-reactive epitope from the capsid protein and can eliminate virus from persistently infected macrophagesRole of dendritic cells in differential susceptibility to viral demyelinating disease.An attenuated variant of the GDVII strain of Theiler's virus does not persist and does not infect the white matter of the central nervous systemGamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infectionTheiler's virus infection of perforin-deficient mice.Protection against lethal encephalomyocarditis virus infection in the absence of serum-neutralizing antibodies.H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virusHigh numbers of viral RNA copies in the central nervous system of mice during persistent infection with Theiler's virus.CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.The majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 miceDA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression.Restraint stress fails to render C57BL/6 mice susceptible to Theiler's virus-induced demyelinationIn vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infectionModeling the acute and chronic phases of Theiler murine encephalomyelitis virus infection.Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.Apoptosis of hippocampal pyramidal neurons is virus independent in a mouse model of acute neurovirulent picornavirus infectionTransition from acute to persistent Theiler's virus infection requires active viral replication that drives proinflammatory cytokine expression and chronic demyelinating disease.A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.
P2860
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P2860
An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
An early, abundant cytotoxic T ...... r preventing viral persistence
@ast
An early, abundant cytotoxic T ...... r preventing viral persistence
@en
type
label
An early, abundant cytotoxic T ...... r preventing viral persistence
@ast
An early, abundant cytotoxic T ...... r preventing viral persistence
@en
prefLabel
An early, abundant cytotoxic T ...... r preventing viral persistence
@ast
An early, abundant cytotoxic T ...... r preventing viral persistence
@en
P2093
P2860
P1433
P1476
An early, abundant cytotoxic T ...... r preventing viral persistence
@en
P2093
Dethlefs S
Larsson-Sciard EL
P2860
P304
P407
P577
1997-11-01T00:00:00Z