Transcriptional activities of mutant p53: when mutations are more than a loss.
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Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parametersMutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type IITranscriptional control of cancer metastasisPTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistanceModulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequencesMutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of functionAltered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.17-N-Allylamino-17-demethoxygeldanamycin induces a diverse response in human acute myelogenous cells.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway.Mutant p53: one name, many proteins.Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.Kaiso depletion attenuates the growth and survival of triple negative breast cancer cellsThe versatile interactions of p53 with DNA: when flexibility serves specificity.Interactions of mutant p53 with DNA: guilt by association.Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expressionMutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.RHAMM splice variants confer radiosensitivity in human breast cancer cell linesDifferential regulation of the REGγ-proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells.Mutant p53 mediates survival of breast cancer cellsBacterial Carriers for Glioblastoma TherapyOverexpression of p53 protein in human tumors.Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks.Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.Recognition of Local DNA Structures by p53 Protein.Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells.HBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion.Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.Mutants TP53 p.R273H and p.R273C but not p.R273G enhance cancer cell malignancy.The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.Dose-dependent dual effect of HTLV-1 tax oncoprotein on p53-dependent nucleotide excision repair in human T-cells.Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.Co-expression of p16 and p53 characterizes aggressive subtypes of ductal intraepithelial neoplasia.
P2860
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P2860
Transcriptional activities of mutant p53: when mutations are more than a loss.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Transcriptional activities of mutant p53: when mutations are more than a loss.
@ast
Transcriptional activities of mutant p53: when mutations are more than a loss.
@en
type
label
Transcriptional activities of mutant p53: when mutations are more than a loss.
@ast
Transcriptional activities of mutant p53: when mutations are more than a loss.
@en
prefLabel
Transcriptional activities of mutant p53: when mutations are more than a loss.
@ast
Transcriptional activities of mutant p53: when mutations are more than a loss.
@en
P2860
P356
P1476
Transcriptional activities of mutant p53: when mutations are more than a loss.
@en
P2093
Wolfgang Deppert
P2860
P304
P356
10.1002/JCB.20271
P577
2004-11-01T00:00:00Z