Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice
about
Initiation of DNA replication at the human beta-globin 3' enhancer.Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital developmentInvestigations of a human embryonic globin gene silencing element using YAC transgenic mice.Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic miceLocalization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus.Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Genomic editing tools to model human diseases with isogenic pluripotent stem cells.Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locusContext-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease.Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain.The A gamma-globin 3' element provides no unique function(s) for human beta-globin locus gene regulation.Persistent fetal gamma-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Agamma-globin gene.Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.Individual LCR hypersensitive sites cooperate to generate an open chromatin domain spanning the human beta-globin locus.Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.Developmental control of epsilon- and gamma-globin genes.Multiple epsilon-promoter elements participate in the developmental control of epsilon-globin genes in transgenic mice.
P2860
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P2860
Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice
description
1997 nî lūn-bûn
@nan
1997年の論文
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1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
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1997年论文
@zh-cn
name
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@ast
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@en
type
label
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@ast
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@en
prefLabel
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@ast
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@en
P2093
P2860
P356
P1476
Mutation of gene-proximal regu ...... ial chromosome transgenic mice
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.1.169
P407
P577
1997-01-01T00:00:00Z