Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
about
The TR2 and TR4 orphan nuclear receptors repress Gata1 transcriptionAn embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimerEKLF and KLF2 have compensatory roles in embryonic beta-globin gene expression and primitive erythropoiesisSox6 directly silences epsilon globin expression in definitive erythropoiesis.Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathiesThe Orphan Nuclear Receptor TR4 Is a Vitamin A-activated Nuclear ReceptorThe human beta-globin locus control regionInduction of human gamma globin gene expression by histone deacetylase inhibitorsPGC-1 coactivator activity is required for murine erythropoiesis.All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic miceInvestigations of a human embryonic globin gene silencing element using YAC transgenic mice.Control of globin gene expression during development and erythroid differentiationIdentification of cis-regulatory sequences in the human angiotensinogen gene by transgene coplacement and site-specific recombination.Adult stage gamma-globin silencing is mediated by a promoter direct repeat element.DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic miceGenomic imprinting recapitulated in the human beta-globin locus.Krüppel-like factors: three fingers in many pies.Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor EklfGeneration of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencingCompound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genesMBD2 contributes to developmental silencing of the human ε-globin gene.Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Characterization of the human beta-globin downstream promoter region.Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells.Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypesErythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivativesDynamic posttranscriptional regulation of epsilon-globin gene expression in vivo.Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancerThe multifunctional role of EKLF/KLF1 during erythropoiesis.Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoterLinear distance from the locus control region determines epsilon-globin transcriptional activity.JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogenyRegulation of human fetal hemoglobin: new players, new complexities.Multiple roles of COUP-TFII in cancer initiation and progressionA single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulationThe H19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.TRIM28 is essential for erythroblast differentiation in the mouse.Advances in the understanding of haemoglobin switching.Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.
P2860
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P2860
Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@ast
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@en
type
label
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@ast
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@en
prefLabel
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@ast
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@en
P2093
P2860
P356
P1433
P1476
Context-dependent EKLF respons ...... cells of YAC transgenic mice.
@en
P2093
P2860
P304
P356
10.1101/GAD.822500
P577
2000-11-01T00:00:00Z