Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.
about
Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kineticsFc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signalingCompartmentalized IgE receptor-mediated signal transduction in living cellsA lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylationTransphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregationAggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTPIdentification of UNC119 as a novel activator of SRC-type tyrosine kinasesAntigen binding characteristics of immunoglobulin free light chains: crosslinking by antigen is essential to induce allergic inflammationPositive and negative regulation of mast cell activation by Lyn via the FcepsilonRIProtein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cellsPhospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathwayPhosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsActivation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and FgrDownstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorSyk-dependent phosphorylation of Shc. A potential link between FcepsilonRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgEAssociation of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells.Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.Functional analysis of activating receptor LMIR4 as a counterpart of inhibitory receptor LMIR3.Interaction between the unphosphorylated receptor with high affinity for IgE and Lyn kinase.Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein.The SCHOOL of nature: I. Transmembrane signaling.Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activationAdapters in the organization of mast cell signaling.Molecular versatility of antibodies.A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells.One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors.Lyn kinase promotes erythroblast expansion and late-stage development.Transmembrane adaptor proteins in the high-affinity IgE receptor signalingShuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular responseG protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation.Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading.Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells.Observing FcepsilonRI signaling from the inside of the mast cell membrane.Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells.The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation.The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1.Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas.
P2860
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P2860
Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@ast
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@en
type
label
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@ast
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@en
prefLabel
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@ast
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@en
P2093
P2860
P356
P1476
Aggregation of the high-affini ...... 56lyn protein-tyrosine kinase.
@en
P2093
P2860
P304
11251-11255
P356
10.1073/PNAS.91.23.11251
P407
P577
1994-11-01T00:00:00Z