A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential
about
Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy.A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.CP-115,953 stimulates cytokine production by lymphocytes.Topoisomerase IV catalysis and the mechanism of quinolone action.A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
P2860
A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential
description
1993 nî lūn-bûn
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1993年の論文
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name
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@ast
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@en
type
label
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@ast
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@en
prefLabel
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@ast
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@en
P2093
P2860
P356
P1476
A pyrimido[1,6-a]benzimidazole ...... drugs with cytotoxic potential
@en
P2093
A H Corbett
N Osheroff
P Pflieger
P2860
P304
P356
10.1128/AAC.37.12.2599
P407
P577
1993-12-01T00:00:00Z