A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
about
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementDirect monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activationImportance of the fourth alpha-helix within the CAP homology domain of type II topoisomerase for DNA cleavage site recognition and quinolone action.Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme.Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.Antifungal activity of eupolauridine and its action on DNA topoisomerasesDual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosisTopoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy.Etoposide quinone is a redox-dependent topoisomerase II poisonDirect measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplificationHuman topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cellsCiprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalphaSubstituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalphaA mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors.Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.In vitro evolution of preferred topoisomerase II DNA cleavage sites.Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.Etoposide quinone is a covalent poison of human topoisomerase IIβ.Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaksTopoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.Topoisomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes.A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.
P2860
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P2860
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@en
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@nl
type
label
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@en
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@nl
prefLabel
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@en
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@nl
P2093
P2860
P356
P1476
A yeast type II topoisomerase ...... persensitivity to ellipticine.
@en
P2093
P2860
P304
P356
10.1074/JBC.270.4.1913
P407
P577
1995-01-01T00:00:00Z