Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells.
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Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagminCharacterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)Functional and biochemical analysis of the C2 domains of synaptotagmin IVRole of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle dockingSynaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosisAlternative splicing of synaptotagmins involving transmembrane exon skippingIdentification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain.Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cellsSynaptotagmin VII regulates Ca(2+)-dependent exocytosis of lysosomes in fibroblastsRNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cellsA novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoformsConserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and XPhysiological aspects of exocytosis in chromaffin cells of the adrenal medulla.The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones.Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance.Rapid regulated dense-core vesicle exocytosis requires the CAPS protein.The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I.Formation of crystalloid endoplasmic reticulum induced by expression of synaptotagmin lacking the conserved WHXL motif in the C terminus. Structural importance of the WHXL motif in the C2B domain.Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III.Is double C2 protein (DOC2) expressed in bovine adrenal medulla? A commercial anti-DOC2 monoclonal antibody recognizes a major bovine mitochondrial antigenExternal Ca2+ dependency of synaptic transmission in drosophila synaptotagmin I mutants.Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells.Drosophila AD3 mutation of synaptotagmin impairs calcium-dependent self-oligomerization activity.Inositol 1,3,4,5-tetrakisphosphate binding activities of neuronal and non-neuronal synaptotagmins. Identification of conserved amino acid substitutions that abolish inositol 1,3,4,5-tetrakisphosphate binding to synaptotagmins III, V, and X.
P2860
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P2860
Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@ast
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@en
type
label
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@ast
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@en
prefLabel
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@ast
Distinct roles of C2A and C2B ...... s in adrenal chromaffin cells.
@en
P2093
P2860
P356
P1476
Distinct roles of C2A and C2B ...... is in adrenal chromaffin cells
@en
P2093
K Kumakura
K Mikoshiba
M Kawasaki
M Ohara-Imaizumi
T Murakami
P2860
P304
P356
10.1073/PNAS.94.1.287
P407
P577
1997-01-01T00:00:00Z