Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy. - Wikidata - awgldk - TriplyDB

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

http://www.wikidata.org/entity/Q35916142

about

A transposon and transposase system for human application Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications Lentiviral vector gene therapy: effective and safe?T cell receptor gene therapy for cancer Gene therapy for severe combined immunodeficiency: are we there yet?Retroviral integrations in gene therapy trials Hematopoietic stem cell engineering at a crossroads Gene therapy studies in a canine model of X-linked severe combined immunodeficiency Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.Long-term vector integration site analysis following retroviral mediated gene transfer to hematopoietic stem cells for the treatment of HIV infection.Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity.Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.Comparing DNA integration site clusters with scan statistics.Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.Deciphering the code for retroviral integration target site selection Vector integration and tumorigenesis.High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion.Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial Neonatal intravenous injection of a gammaretroviral vector has a low incidence of tumor induction in mice.Methodology and software to detect viral integration site hot-spots.Analyzing the number of common integration sites of viral vectors--new methods and computer programs.Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.Estimating abundances of retroviral insertion sites from DNA fragment length data.High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.Adeno-associated virus-mediated gene transfer The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites.Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy.Linear amplification mediated PCR--localization of genetic elements and characterization of unknown flanking DNA.Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.Genomic discovery of potent chromatin insulators for human gene therapy.LMO2 induces T-cell leukemia with epigenetic deregulation of CD4 Tracking of specific integrant clones in dogs treated with foamy virus vectors.

P2860

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P2860

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.

http://www.wikidata.org/entity/Q35916142

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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type

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Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

@ast

Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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P1433

Journal of Clinical Investigation

P1476

Vector integration is nonrando ...... iesis in SCID-X1 gene therapy.

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P2093

Annette Deichmann

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Bernard Prum

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Christophe Hue

http://www.w3.org/2001/XMLSchema#string

Christopher C Fraser

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Chuck Klanke

http://www.w3.org/2001/XMLSchema#string

Claudia Prinz

http://www.w3.org/2001/XMLSchema#string

Dick de Ridder

http://www.w3.org/2001/XMLSchema#string

Frank J T Staal

http://www.w3.org/2001/XMLSchema#string

Gabor Gyapay

http://www.w3.org/2001/XMLSchema#string

Gerard Wagemaker

http://www.w3.org/2001/XMLSchema#string

P2860

Comprehensive genome sequence analysis of a breast cancer amplicon

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

Transcription start regions in the human genome are favored targets for MLV integration

HIV-1 integration in the human genome favors active genes and local hotspots

Relationship between retroviral DNA-integration-site selection and host cell transcription.

Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

P304

2225-2232

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scholarly article

P356

10.1172/JCI31659

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P433

8

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P478

117

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P50

Christof von Kalle

Marina Cavazzana-Calvo

Jean Weissenbach

Salima Hacein-Bey-Abina

Jean-Luc Villeval

Alexandrine Garrigue

Ian E. Alexander

Martijn Brugman

P577

2007-08-01T00:00:00Z

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P5875

6166971

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P698

17671652

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P932

1934585

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