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Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesisLentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapyRetroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.The genomic risk of somatic gene therapy.Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression.Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.Gene therapy: is IL2RG oncogenic in T-cell development?Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.Resistance of mature T cells to oncogene transformation.Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutationsAvoiding cytotoxicity of transposases by dose-controlled mRNA delivery
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description
onderzoeker
@nl
researcher
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հետազոտող
@hy
name
Martijn Brugman
@ast
Martijn Brugman
@en
Martijn Brugman
@es
Martijn Brugman
@nl
Martijn Brugman
@sl
type
label
Martijn Brugman
@ast
Martijn Brugman
@en
Martijn Brugman
@es
Martijn Brugman
@nl
Martijn Brugman
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M. Brugman
@nl
prefLabel
Martijn Brugman
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Martijn Brugman
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Martijn Brugman
@es
Martijn Brugman
@nl
Martijn Brugman
@sl
P106
P31
P496
0000-0003-2675-2705