Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. - Wikidata - awgldk - TriplyDB

Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.

Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.

http://www.wikidata.org/entity/Q35921730

about

Modulation of the Coagulation Cascade Using Aptamers Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa.Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation.Differential Contributions of Intrinsic and Extrinsic Pathways to Thrombin Generation in Adult, Maternal and Cord Plasma Samples.Prediction of aptamer-protein interacting pairs using an ensemble classifier in combination with various protein sequence attributes Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant.Rapid Complexation of Aptamers by Their Specific Antidotes.Aptamers in HIV research diagnosis and therapy.Structural optimization of an aptamer generated from Ligand-Guided Selection (LIGS) resulted in high affinity variant toward mIgM expressed on Burkitt's lymphoma cell lines.Generation and characterization of aptamers targeting factor XIa.A kallikrein-targeting RNA aptamer inhibits the intrinsic pathway of coagulation and reduces bradykinin release.

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P2860

Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.

http://www.wikidata.org/entity/Q35921730

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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name

Potent anticoagulant aptamer d ...... lecular substrate interaction.

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Potent anticoagulant aptamer d ...... lecular substrate interaction.

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Potent anticoagulant aptamer d ...... lecular substrate interaction.

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Potent anticoagulant aptamer d ...... lecular substrate interaction.

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Potent anticoagulant aptamer d ...... lecular substrate interaction.

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Potent anticoagulant aptamer d ...... lecular substrate interaction.

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JBC.M111.300772

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Journal of Biological Chemistry

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Potent anticoagulant aptamer d ...... olecular substrate interaction

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Bruce Sullenger

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Rebecca Woodruff

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P2860

Crystal structure of an RNA aptamer bound to thrombin

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

In vitro selection of RNA molecules that bind specific ligands

Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)

A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors.

Aptamers: an emerging class of therapeutics.

RNA aptamers as reversible antagonists of coagulation factor IXa.

A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery.

Heparinless cardiopulmonary bypass with active-site blocked factor IXa: a preliminary study on the dog.

Characterization of the clotting activities of structurally different forms of activated factor IX. Enzymatic properties of normal human factor IXa alpha, factor IXa beta, and activated factor IX Chapel Hill.

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12779-12786

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scholarly article

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10.1074/JBC.M111.300772

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16

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287

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Dougald M. Monroe

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2012-02-13T00:00:00Z

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22334679

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anticoagulation

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