Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
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Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthasesInhibition Kinetics and Emodin Cocrystal Structure of a Type II Polyketide Ketoreductase † , ‡Structural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseStructural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and RegiospecificitiesThe Determinants of Activity and Specificity in Actinorhodin Type II Polyketide KetoreductaseInsights into the bioactivity of mensacarcin and epoxide formation by MsnO8Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pecEctopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapesMicrobial polyketide synthases: more and more prolific.Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.Structural enzymology of polyketide synthases.Cyclization of aromatic polyketides from bacteria and fungiBiosynthesis of colabomycin E, a new manumycin-family metabolite, involves an unusual chain-length factor.The enzymology of combinatorial biosynthesis.Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2).Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms.Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthasesEngineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.Evolutionally guided enzyme design.Biosynthesis of aromatic polyketides in bacteria.Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthaseInhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder.The role of transcription in heterologous expression of polyketides in bacterial hosts.Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL.Antibacterial polyketides from the marine alga-derived endophitic Streptomyces sundarbansensis: a study on hydroxypyrone tautomerism.Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tü2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier proteinSystematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.Kinetic analysis of the actinorhodin aromatic polyketide synthase.Redirecting the cyclization steps of fungal polyketide synthase.In vivo and in vitro analysis of the hedamycin polyketide synthase.Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.Engineering of novel polyketides. Progress and Prospects.Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits.Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.Aromatic Polyketide GTRI-02 is a Previously Unidentified Product of the act Gene Cluster in Streptomyces coelicolor A3(2).Insights into lasalocid A ring formation by chemical chain termination in vivo.Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae.
P2860
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P2860
Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@ast
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@en
type
label
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@ast
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@en
prefLabel
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@ast
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@en
P2093
P2860
P356
P1476
Engineered biosynthesis of nov ...... aromatic polyketide synthase.
@en
P2093
P2860
P304
11542-11546
P356
10.1073/PNAS.91.24.11542
P407
P577
1994-11-01T00:00:00Z