Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.

Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.

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http://www.wikidata.org/entity/Q46691158
Evolution of polyketide synthases in bacteriaChemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.Oxytetracycline biosynthesis.Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Genetics of Streptomyces rimosus, the oxytetracycline producer.Decoding and engineering tetracycline biosynthesis.The structural role of the carrier protein--active controller or passive carrier.Heterologous expression and manipulation of three tetracycline biosynthetic pathways.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIIEngineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.Heterologous expression of oxytetracycline biosynthetic gene cluster in Streptomyces venezuelae WVR2006 to improve production level and to alter fermentation process.
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Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.

Item
http://www.wikidata.org/entity/Q46691158
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Ablation of the otcC gene enco ...... des with altered chain length.
@en
Ablation of the otcC gene enco ...... des with altered chain length.
@nl
type
label
Ablation of the otcC gene enco ...... des with altered chain length.
@en
Ablation of the otcC gene enco ...... des with altered chain length.
@nl
prefLabel
Ablation of the otcC gene enco ...... des with altered chain length.
@en
Ablation of the otcC gene enco ...... des with altered chain length.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
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P478
P577
P698
P356
P1433
P1476
Ablation of the otcC gene enco ...... des with altered chain length.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698