Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. - Wikidata - awgldk - TriplyDB

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding.

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding.

http://www.wikidata.org/entity/Q35922618

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Wine polyphenols: potential agents in neuroprotection Ferulic Acid: A Hope for Alzheimer's Disease Therapy from Plants Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly A microliter-scale high-throughput screening system with quantum-dot nanoprobes for amyloid-β aggregation inhibitors Methylated derivatives of myricetin enhance life span in Caenorhabditis elegans dependent on the transcription factor DAF-16.Structural determinants of Tau aggregation inhibitor potency Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline.Growth and Accumulation of Secondary Metabolites in Perilla as Affected by Photosynthetic Photon Flux Density and Electrical Conductivity of the Nutrient Solution.Structure and mechanism of action of tau aggregation inhibitors.Mass spectrometry as an efficient tool for the characterization of amyloid β peptide 25-35 self-assembly species in aggregation and inhibition studies.Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.Natural biomolecules and protein aggregation: emerging strategies against amyloidogenesis Fine mapping of the amyloid β-protein binding site on myelin basic protein.Protein folding and aggregation into amyloid: the interference by natural phenolic compounds Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease.Cognitive-enhancing and antioxidant activities of the aqueous extract from Markhamia tomentosa (Benth.) K. Schum. stem bark in a rat model of scopolamine.Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's disease Natural polyphenols binding to amyloid: a broad class of compounds to treat different human amyloid diseases.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Flavonoids are determinants of freezing tolerance and cold acclimation in Arabidopsis thaliana Mechanisms for the inhibition of amyloid aggregation by small ligands.Potential of Different Coleus blumei Tissues for Rosmarinic Acid Production.Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment.Protein folding, misfolding and aggregation: The importance of two-electron stabilizing interactions.Capping of aβ42 oligomers by small molecule inhibitors.Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ₂₅₋₃₅-induced neurotoxicity through mitochondria pathway.Bioactive stilbenes from Vitis vinifera grapevine shoots extracts.Rosmarinic acid inhibits chemical hypoxia-induced cytotoxicity in primary cultured rat hepatocytes.Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons.Effects of antiparkinsonian agents on β-amyloid and α-synuclein oligomer formation in vitro.The cardioprotective effect of rosmarinic acid on acute myocardial infarction and genes involved in Ca2+ homeostasis.Study on the inter- and intra-peptide salt-bridge mechanism of Aβ23-28 oligomer interaction with small molecules: QM/MM method.Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity.

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P2860

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding.

http://www.wikidata.org/entity/Q35922618

description

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Phenolic compounds prevent amy ...... tion by site-specific binding.

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Phenolic compounds prevent amy ...... tion by site-specific binding.

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Akihiko Takashima

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David B Teplow

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Fang Han

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Hisao Nishijo

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Jun-ichi Takasaki

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Kenjiro Ono

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Lei Li

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Lijun Zhu

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Masahito Yamada

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Michael G Zagorski

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P2860

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Human serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanism

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity

The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Biological effects of myricetin

Abeta mediated diminution of MTT reduction--an artefact of single cell culture?

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3340280

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