A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
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Death receptor-ligand systems in cancer, cell death, and inflammationPerforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Interleukin-18 protects mice against acute herpes simplex virus type 1 infection.Theiler's virus infection of perforin-deficient mice.Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes.Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice.Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic miceCD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection.Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.Prostate-specific antigen vaccines for prostate cancer.Cytolytic pathways in haematopoietic stem-cell transplantation.Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis.Granzymes and perforin in solid organ transplant rejection.Differential effects of stimulatory factors on natural killer cell activities of young and aged mice.Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host diseaseDevelopment of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicityCytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice.In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells.Gamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease.Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes.Mechanisms of granule-dependent killing.CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillanceA mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantationEffects of butyltins on mitogen-activated-protein kinase kinase kinase and Ras activity in human natural killer cells.The immunological functions of saposins.Orphan granzymes find a home.Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer.Granzyme M: behind enemy lines.Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.Ultraviolet light modulation of autoantigens, epidermal cytokines and adhesion molecules as contributing factors of the pathogenesis of cutaneous LE.The influence of ultraviolet light on immunological cytotoxicity in the skin.Molecular mechanism of target lysis by cytotoxic T cells.Fas-mediated apoptosis is involved in the elimination of gene-transduced hepatocytes with E1/E3-deleted adenoviral vectors.Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.IAPs, TNF, inflammation and Jürg Tschopp; a personal perspective.Role of the perforin/granzyme cell death pathway in D-Gal/LPS-induced inflammatory liver injury.
P2860
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P2860
A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@ast
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@en
type
label
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@ast
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@en
prefLabel
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@ast
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@en
P2093
P2860
P356
P1476
A null mutation in the perfori ...... er cell-mediated cytotoxicity.
@en
P2093
P2860
P304
11571-11575
P356
10.1073/PNAS.91.24.11571
P407
P50
P577
1994-11-01T00:00:00Z