Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. - Wikidata - awgldk - TriplyDB

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

http://www.wikidata.org/entity/Q35927921

about

Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation Tamoxifen-induced epigenetic silencing of oestrogen-regulated genes in anti-hormone resistant breast cancer OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet Epigenetic disruption of cell signaling in nasopharyngeal carcinoma.The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer Frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer.Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer A microRNA contribution to aberrant Ras activation in gastric cancer Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.Methylation determines fibroblast activation and fibrogenesis in the kidney.Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells Differential Regulation of RasGAPs in Cancer.Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway.The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas.Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.DACT1, an antagonist to Wnt/β-catenin signaling, suppresses tumor cell growth and is frequently silenced in breast cancer.Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer Annexin A6 is down-regulated through promoter methylation in gastric cancer.Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma.DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells.Inhibition and termination of physiological responses by GTPase activating proteins.The role of promoter hypermethylation in fibroblast activation and fibrogenesis.Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.Contribution of genetics and epigenetics to progression of kidney fibrosis.Regulation and function of mitophagy in development and cancer.Epigenetic Alterations in Epstein-Barr Virus-Associated Diseases.DLEC1, a 3p tumor suppressor, represses NF-κB signaling and is methylated in prostate cancer.Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling.RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway.Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas.In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance.NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor inactivated by promoter hypermethylation in nasopharyngeal carcinoma.Unravelling the mechanism of dual-specificity GAPs.

P2860

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P2860

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

http://www.wikidata.org/entity/Q35927921

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2007 nî lūn-bûn

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2007年学术文章

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2007年學術文章

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Epigenetic silencing of a Ca(2 ...... s activation in human cancers.

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Epigenetic silencing of a Ca(2 ...... s activation in human cancers.

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Epigenetic silencing of a Ca(2 ...... s activation in human cancers.

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Epigenetic silencing of a Ca(2 ...... s activation in human cancers.

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Epigenetic silencing of a Ca(2 ...... s activation in human cancers.

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Proceedings of the National Academy of Sciences of the United States of America

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Epigenetic silencing of a Ca(2 ...... as activation in human cancers

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Ada H Y Wong

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En-Min Li

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Gopesh Srivastava

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Hongchuan Jin

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Jianming Ying

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Jie Jin

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Qian Zhang

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Sabine Kupzig

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Yan Cui

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Zhong-Ying Shen

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P2860

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway

The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2

Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase

CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.

Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

Targeting RAS signalling pathways in cancer therapy

RASA1: variable phenotype with capillary and arteriovenous malformations

A genetic screen for candidate tumor suppressors identifies REST

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

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104

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Anthony Tak-Cheung Chan

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