Widely distributed noncoding purifying selection in the human genome.
about
A user's guide to the encyclopedia of DNA elements (ENCODE)Human genetics and genomics a decade after the release of the draft sequence of the human genomeWidespread purifying selection on RNA structure in mammalsAn integrated encyclopedia of DNA elements in the human genomePairomics, the omics way to mate choiceMethods to detect selection on noncoding DNAExploring the role of copy number variants in human adaptationExplaining human uniqueness: genome interactions with environment, behaviour and cultureNatural Selection and Functional Potentials of Human Noncoding Elements Revealed by Analysis of Next Generation Sequencing DataAnalysis of sequence conservation at nucleotide resolutionHypermutable non-synonymous sites are under stronger negative selectionCryptic variation in the human mutation rate.Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergenceHuman triallelic sites: evidence for a new mutational mechanism?Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomesEvolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.Purifying selection in deeply conserved human enhancers is more consistent than in coding sequences.Sequencing studies in human genetics: design and interpretation.Molecular spandrels: tests of adaptation at the genetic level.Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome.Strain screen and haplotype association mapping of wheel running in inbred mouse strains.Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypesA genome-wide comparison of the functional properties of rare and common genetic variants in humansWhich Genetics Variants in DNase-Seq Footprints Are More Likely to Alter Binding?Comprehensive identification and analysis of human accelerated regulatory DNAThe QTN program and the alleles that matter for evolution: all that's gold does not glitterThe other side of the nearly neutral theory, evidence of slightly advantageous back-mutations.Personal and population genomics of human regulatory variation.Comparative and evolutionary insights into CD4 gene across mammalian and avian taxa.Accelerated sequence divergence of conserved genomic elements in Drosophila melanogasterInterpreting noncoding genetic variation in complex traits and human disease.Evolutionary evidence of the effect of rare variants on disease etiology.The central role of RNA in human development and cognition.Variation in the mutation rate across mammalian genomes.The impact of cis-acting polymorphisms on the human phenotype.Detecting past positive selection through ongoing negative selection.The Time Scale of Recombination Rate Evolution in Great Apes.Prevalence of multinucleotide replacements in evolution of primates and Drosophila.Mutations within lncRNAs are effectively selected against in fruitfly but not in human.
P2860
Q21092716-E1B7A754-FB51-49C9-8B8B-D39927A44D7AQ21245451-79A98550-24E2-4EA4-B16C-6B6CE147DA90Q22065971-0BA06D2E-0635-4BA2-A593-85573613C0DAQ22122150-3A076661-4F43-4A5A-811E-72D09929305FQ26809970-D6C57BC8-552C-4B1E-9855-26B9405AF76FQ26852755-6557EF62-A9D9-4B53-977E-3277DE91A889Q28263929-D66FC2BC-2A31-49AB-9AC3-044DF784FC18Q28750822-C56410CA-57B0-4B90-BC54-13E4018E9D76Q30000328-13C3C694-5495-45B6-B68A-5AE5F0EF0D24Q33312848-06A586F0-8CCA-4EDB-995F-B260BF7B8303Q33388221-D8BE4061-D547-4AE0-AA6C-7DDA2B9BC9A9Q33405561-3FA0C5A6-FB59-4ECA-9F2A-F29EC0598C16Q33491547-31291B2D-B877-4063-A7DB-C17895AFB7DDQ33628441-EEA70115-6963-4E1E-83DC-9DC3C424F3F1Q33736558-04FD2E1E-8353-45D9-8D89-12D44BE53519Q33844411-7531ED8C-6B43-4102-A4A1-7628089896ACQ33883110-AC7CF208-6E6C-41C8-9FD7-EDCDB63B22DEQ33952379-2B7E0157-D2CE-4CE9-A25C-F7EA3C32D08FQ33981063-12437C83-35ED-41C7-9A5C-ED1D82993F05Q34049975-EA5A5910-101E-4E68-8AA2-28EA431298BAQ34055381-BB738F48-DEAA-4C0D-9905-F87A3C0A593AQ34151309-21BA5FE9-EAE3-4D88-8EA1-F1A0367BA464Q34300842-1AED683A-9574-44AE-A138-4D3046218995Q34768431-E0A0C9B5-F23D-4B4C-B2EB-6E5490754347Q35930706-FB479914-AC46-47A7-8DB5-D2666156DBE9Q36032469-9D4FD711-D912-4748-B639-B1252CDFC0CCQ36067676-229AE7E0-E40F-4F15-9547-FE22971A4307Q36089115-F7773729-57FB-4867-9418-C852A341C637Q36201219-BF03722C-BAA7-4A92-A3DC-E61053B89A03Q36430009-A6EEDCFC-30E8-49DD-A429-72034D338F9AQ36915070-D0585E0A-05F3-4D57-9D16-8B67D9F201AEQ36988784-7BDF9EF7-EF89-4463-85BA-62B84152EFBCQ37787322-9B3AA800-2091-4037-9C05-0C6276305A47Q37873983-678581C7-8449-430A-94F5-787C9685895BQ37942062-75B77530-A8C7-482E-966F-DBF85BC8812EQ38064462-F090DFD3-A555-4CAE-9C85-B60302648D2DQ38606458-A9194F0D-545F-4342-BC96-5C1BCBD74536Q40208191-88B4A8DD-1BDC-42E7-A1F7-BC9D1CC86409Q40577986-5A789FA3-448E-4175-8AE5-884E288110EBQ40593966-3AD6C04C-4E8F-41EF-8B36-D8D077CBEC23
P2860
Widely distributed noncoding purifying selection in the human genome.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Widely distributed noncoding purifying selection in the human genome.
@ast
Widely distributed noncoding purifying selection in the human genome.
@en
type
label
Widely distributed noncoding purifying selection in the human genome.
@ast
Widely distributed noncoding purifying selection in the human genome.
@en
prefLabel
Widely distributed noncoding purifying selection in the human genome.
@ast
Widely distributed noncoding purifying selection in the human genome.
@en
P2093
P2860
P356
P1476
Widely distributed noncoding purifying selection in the human genome.
@en
P2093
Charles E Grant
Gregory Kryukov
Saurabh Asthana
Shamil Sunyaev
William S Noble
P2860
P304
12410-12415
P356
10.1073/PNAS.0705140104
P407
P577
2007-07-17T00:00:00Z