LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
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The macrophage migration inhibitory factor homolog of Entamoeba histolytica binds to and immunomodulates host macrophages.NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.PUMA: a unified framework for penalized multiple regression analysis of GWAS data11β-hydroxysteroid dehydrogenase 1 specific inhibitor increased dermal collagen content and promotes fibroblast proliferation.Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolismTNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis.Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells.Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance.Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function.Liver receptor homolog 1 is essential for ovulation.Cortisol synthesis in epidermis is induced by IL-1 and tissue injury.Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitisImmunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization.LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.Macrolides increase the expression of 11β-hydroxysteroid dehydrogenase 1 in human sinonasal epithelium, contributing to glucocorticoid activation in sinonasal mucosa.Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Emerging actions of the nuclear receptor LRH-1 in the gut.Enterococcus faecalis from newborn babies regulate endogenous PPARgamma activity and IL-10 levels in colonic epithelial cells.Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.Gastrointestinal inflammation: lessons from metabolic modulators.Biliary Phospholipids Sustain Enterocyte Proliferation and Intestinal Tumor Progression via Nuclear Receptor Lrh1 in mice.Liver receptor homolog-1 is essential for pregnancy.Orphan nuclear receptors as targets for drug development.Why does the gut synthesize glucocorticoids?A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer.Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions.Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.Local glucocorticoid production in the mouse lung is induced by immune cell stimulation.The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells.LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesisNuclear receptor NR5A2 controls neural stem cell fate decisions during development.Colon cancer cells produce immunoregulatory glucocorticoidsNuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.LRH-1: orphaned, adopted and needed for pregnancy.Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa.Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism.
P2860
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P2860
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@ast
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@en
type
label
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@ast
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@en
prefLabel
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@ast
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@en
P2093
P2860
P50
P356
P1476
LRH-1-mediated glucocorticoid ...... st inflammatory bowel disease.
@en
P2093
Agnes Coste
Benjamin Magnier
Jean-Sebastien Annicotte
Maria Cristina Antal
Mario Notti
Nadia Corazza
Romain Barnouin
Thomas Brunner
P2860
P304
13098-13103
P356
10.1073/PNAS.0702440104
P407
P577
2007-08-01T00:00:00Z