Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques - Wikidata - awgldk - TriplyDB

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

http://www.wikidata.org/entity/Q35941408

about

Drug transporters in tissues and cells relevant to sexual transmission of HIV: Implications for drug delivery Chemokine receptor CCR5 antagonist maraviroc: medicinal chemistry and clinical applications Development and bioanalytical validation of a liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the quantification of the CCR5 antagonist maraviroc in human plasma.Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.Pharmacokinetics of antiretrovirals in genital secretions and anatomic sites of HIV transmission: implications for HIV prevention.Pharmacokinetics and preliminary safety study of pod-intravaginal rings delivering antiretroviral combinations for HIV prophylaxis in a macaque model.Electrospun solid dispersions of Maraviroc for rapid intravaginal preexposure prophylaxis of HIV A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques A temperature-monitoring vaginal ring for measuring adherence.A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.ADS-J1 inhibits semen-derived amyloid fibril formation and blocks fibril-mediated enhancement of HIV-1 infection.Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.The nonnucleoside reverse transcription inhibitor MIV-160 delivered from an intravaginal ring, but not from a carrageenan gel, protects against simian/human immunodeficiency virus-RT Infection.A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis.Vaginal rings for delivery of HIV microbicides.Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques In search of the optimal delivery method for anti-HIV microbicides: are intravaginal rings the way forward?Sustained release of the candidate antiretroviral peptides T-1249 and JNJ54310516-AFP from a rod insert vaginal ring Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.Animal models for microbicide safety and efficacy testing.Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.An overview of antiretroviral pre-exposure prophylaxis of HIV infection.Effect of HIV-1 subtype and tropism on treatment with chemokine coreceptor entry inhibitors; overview of viral entry inhibition.Beyond HIV microbicides: multipurpose prevention technology products.Vaginal drug delivery for the localised treatment of cervical cancer.Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

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P2860

Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques

http://www.wikidata.org/entity/Q35941408

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Sustained release of the CCR5 ...... ginal rings in rhesus macaques

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Sustained release of the CCR5 ...... ginal rings in rhesus macaques

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Sustained release of the CCR5 ...... ginal rings in rhesus macaques

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Antimicrobial Agents and Chemotherapy

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Sustained release of the CCR5 ...... ginal rings in rhesus macaques

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Deborah Lowry

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Diarmaid J Murphy

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John P Moore

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Kelsi K Rasmussen

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Lara A Doyle

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Laurie Goldman

http://www.w3.org/2001/XMLSchema#string

Leslie Geer

http://www.w3.org/2001/XMLSchema#string

Per Johan Klasse

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Peter Boyd

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Ronald S Veazey

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P2860

Preexposure chemoprophylaxis for HIV prevention in men who have sex with men

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

Prevention of HIV-1 infection with early antiretroviral therapy

Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs

Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.

Which topical microbicides for blocking HIV-1 transmission will work in the real world?

A vaginal fluid simulant.

Identification of rhesus macaque genital microbiota by 16S pyrosequencing shows similarities to human bacterial vaginosis: implications for use as an animal model for HIV vaginal infection.

Whither or wither microbicides?

HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis.

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10.1128/AAC.05810-11

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2012-02-13T00:00:00Z

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22330914

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3346641

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