Beyond the signal sequence: protein routing in health and disease.
about
Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant ProteinsPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsA phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptorTrafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Salt bridge integrates GPCR activation with protein traffickingThe signal peptide of the IgE receptor alpha-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsRestoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.High-throughput screen for pharmacoperones of the vasopressin type 2 receptorThe B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif.Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.LocSigDB: a database of protein localization signals.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsAssay strategies for identification of therapeutic leads that target protein traffickingRescue of misrouted GnRHR mutants reveals its constitutive activityPrecision targeted ruthenium(ii) luminophores; highly effective probes for cell imaging by stimulated emission depletion (STED) microscopy.Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro.Melanotrope cells as a model to understand the (patho)physiological regulation of hormone secretion.Mitochondrial protein import and human health and disease.Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine.Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.Species sequence differences determine the interaction of GnRH receptor with the cellular quality control systemMutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Chaperone-like effects of cell-permeant ligands on opioid receptors.Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants.Aberrant folding of a mutant Stat5b causes growth hormone insensitivity and proteasomal dysfunction.Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy.A Novel Modeling in Mathematical Biology for Classification of Signal Peptides.The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.Dominant and recessive mutations in rhodopsin activate different cell death pathways.
P2860
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P2860
Beyond the signal sequence: protein routing in health and disease.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Beyond the signal sequence: protein routing in health and disease.
@ast
Beyond the signal sequence: protein routing in health and disease.
@en
type
label
Beyond the signal sequence: protein routing in health and disease.
@ast
Beyond the signal sequence: protein routing in health and disease.
@en
prefLabel
Beyond the signal sequence: protein routing in health and disease.
@ast
Beyond the signal sequence: protein routing in health and disease.
@en
P2093
P356
P1433
P1476
Beyond the signal sequence: protein routing in health and disease.
@en
P2093
Cecilia Castro-Fernández
Guadalupe Maya-Núñez
P Michael Conn
P304
P356
10.1210/ER.2004-0010
P577
2004-11-09T00:00:00Z