Translating slow-binding inhibition kinetics into cellular and in vivo effects
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Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) AntibioticsEndless Resistance. Endless Antibiotics?A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacyMechanism of the Association Pathways for a Pair of Fast and Slow Binding Ligands of HIV-1 Protease.Dissociation Dynamics of XPC-RAD23B from Damaged DNA Is a Determining Factor of NER Efficiency.CNS Anticancer Drug Discovery and Development Conference White Paper.Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase.The drug-target residence time model: a 10-year retrospective.On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targetsDrug-target interaction kinetics: underutilized in drug optimization?Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivoAntibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxC.High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery.Drug-Target Kinetics in Drug Discovery.Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery.CNS Anticancer Drug Discovery and Development: 2016 conference insights.Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.Binding time--not just affinity--gains stature in drug design.Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.Protein-ligand (un)binding kinetics as a new paradigm for drug discovery at the crossroad between experiments and modellingModelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment modelsCellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells
P2860
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P2860
Translating slow-binding inhibition kinetics into cellular and in vivo effects
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@ast
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@en
type
label
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@ast
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@en
prefLabel
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@ast
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@en
P2093
P2860
P356
P1476
Translating slow-binding inhibition kinetics into cellular and in vivo effects
@en
P2093
Allison L Choy
David E Ehmann
Ed T Buurman
Eleanor K H Allen
Fereidoon Daryaee
Grant K Walkup
John O'Donnell
Kerry Murphy-Benenato
Laurel Hajec
Lena A Grosser
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1796
P577
2015-04-20T00:00:00Z