Exploring the link between glucocerebrosidase mutations and parkinsonism
about
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's diseaseGlucocerebrosidase is shaking up the synucleinopathiesImiglucerase in the treatment of Gaucher disease: a history and perspectiveThe Genetic Basis of Cognitive Impairment and Dementia in Parkinson's DiseaseThe crucial impact of lysosomes in aging and longevityParkinson's disease, insulin resistance and novel agents of neuroprotectionGaucher disease and comorbidities: B-cell malignancy and parkinsonismConverging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's diseaseThe relationship between glucocerebrosidase mutations and Parkinson diseaseTool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysatesVisualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based ProbesLIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearanceMitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's diseaseCognitive and Antipsychotic Medication Use in Monoallelic GBA-Related Parkinson Disease.Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations.Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.Greater risk of parkinsonism associated with non-N370S GBA1 mutationsFrontotemporal dementia and its subtypes: a genome-wide association study.Gaucher disease: insights from a rare Mendelian disorder.The link between the GBA gene and parkinsonismThe LIMP-2/SCARB2 binding motif on acid β-glucosidase: basic and applied implications for Gaucher disease and associated neurodegenerative diseases.Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutationCandidate molecules for chemical chaperone therapy of GM1-gangliosidosis.Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease.Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors.Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Gaucher-Associated Parkinsonism.Can the disease course in Parkinson's disease be slowed?The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flowAcidic Ca2+ stores in neurodegeneration.Premotor biomarkers for Parkinson's disease - a promising direction of research.Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity.Transcranial sonography and functional imaging in glucocerebrosidase mutation Parkinson diseaseCharacterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.Saposin C protects glucocerebrosidase against α-synuclein inhibition.A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies.Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson diseaseN-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases.Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration.
P2860
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P2860
Exploring the link between glucocerebrosidase mutations and parkinsonism
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Exploring the link between glucocerebrosidase mutations and parkinsonism
@ast
Exploring the link between glucocerebrosidase mutations and parkinsonism
@en
type
label
Exploring the link between glucocerebrosidase mutations and parkinsonism
@ast
Exploring the link between glucocerebrosidase mutations and parkinsonism
@en
prefLabel
Exploring the link between glucocerebrosidase mutations and parkinsonism
@ast
Exploring the link between glucocerebrosidase mutations and parkinsonism
@en
P2093
P2860
P1476
Exploring the link between glucocerebrosidase mutations and parkinsonism
@en
P2093
Ann Marie Gustafson
Ellen Sidransky
Wendy Westbroek
P2860
P304
P356
10.1016/J.MOLMED.2011.05.003
P577
2011-07-01T00:00:00Z