HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
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Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly modelsHistone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collectionEpigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based ModelsSmall molecule inhibitors of zinc-dependent histone deacetylasesHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activityHDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivoSpatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regenerationExercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary studyCBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine AcetylationAminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea.Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells.Acetylation regulates WRN catalytic activities and affects base excision DNA repair.Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosisHistone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegenerationHistone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function.Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppressionScriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT.Use of epigenetic drugs in disease: an overview.Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock.Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson diseaseThe therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosisTranscription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspectiveProteomic analysis reveals differentially regulated protein acetylation in human amyotrophic lateral sclerosis spinal cord.Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury.HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damageSuberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damageEpigenetic regulation of axon and dendrite growthAcetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation.KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism.Histone deacetylase inhibition and the regulation of cell growth with particular reference to liver pathobiology.Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.A role for epigenetic changes in the development of retinal neurodegenerative conditions.Paraquat induces epigenetic changes by promoting histone acetylation in cell culture models of dopaminergic degeneration.Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
P2860
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P2860
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@ast
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@en
type
label
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@ast
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@en
prefLabel
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@ast
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.
@en
P2860
P356
P1476
HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.CDD.4401769
P577
2006-04-01T00:00:00Z