CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development.
about
Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activityEnhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alphaA comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Evaluating a physiologically based pharmacokinetic model for predicting the pharmacokinetics of midazolam in Chinese after oral administration.Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.The role of cytochrome P450 in antiretroviral drug interactions.Cytochrome P450 reaction-phenotyping: an industrial perspective.Accelerated metabolism of voriconazole and its partial reversal by cimetidineA double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn.Antiviral drug disposition and natural health products: risk of therapeutic alteration and resistance.Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates.Drug-vitamin D interactions: a systematic review of the literatureTranscriptional regulation of human UDP-glucuronosyltransferase genes.Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes.Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells.Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide.Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach.Molecular characterization of two novel deltamethrin-inducible P450 genes from Liposcelis bostrychophila Badonnel (Psocoptera: Liposcelididae).Etoposide pathway.Constitutive expression of drug metabolizing enzymes and related transcription factors in cattle testis and their modulation by illicit steroids.Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.In vitro metabolism of a new cardioprotective agent, KR-32570, in human liver microsomes.Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome p450-inducing medications.Constitutive expression and phenobarbital modulation of drug metabolizing enzymes and related nuclear receptors in cattle liver and extra-hepatic tissues.Three-dimensional microtissues as an in vitro model for personalized radiation therapy.Time-dependent changes in hepatic and intestinal induction of cytochrome P450 3A after administration of dexamethasone to rats.Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage.Role of c-Jun-N-terminal kinase in pregnane X receptor-mediated induction of human cytochrome P4503A4 in vitro.Cytochrome P450 3A expression and function in liver and intestinal mucosa from dexamethasone-treated sheep.Effect of Nicotine on CYP2B1 Expression in a Glioma Animal Model and Analysis of CYP2B6 Expression in Pediatric Gliomas.
P2860
Q28269219-90AC5990-8E65-48F6-9961-7045DFC8C6F7Q28537869-1B8BAB18-A67C-437E-8DDA-405FC5A81005Q33891043-230AC495-D7F9-4B61-BD8D-853C8E61DA20Q35647390-C461AF38-B56B-4787-82F8-DE9376328583Q36113188-6A5BD818-3E9B-4895-935A-F927E3530268Q36440155-E998F7FA-1D2F-4CE2-9863-E2A1AD7D62F6Q36440873-48017884-78DE-4BE8-A9B4-3870699A25A7Q36579268-F669EF8F-A5EA-4212-95F3-08D7876E9383Q36605868-D3B275AB-59BE-42E3-9356-23A6A3E72C60Q36909336-2DD9D8FC-789C-485A-A928-CCD2650AA749Q36960539-7D9F7016-BEC5-46CB-B958-E260ABDC1A97Q37144774-63DC43B5-3875-4926-9F78-A3F9702FD1FBQ37183874-6C1E773E-77BF-4211-827E-E82F26853C83Q37385736-232D1BF2-595A-4145-94C5-3115B4DA6A0DQ37481442-46D6DC39-CD2C-48B7-909A-FF2FD15E1329Q37756178-4D7504B0-8B39-41EB-AF50-B7BD30A9571EQ38017718-BE6A1EB9-136B-46C0-8B78-FED9EC285C48Q38073239-260BE6FA-08AB-454C-9703-12BE17B326D8Q38261875-7C0580CE-0F7B-40F9-819E-94D4278C7398Q38505185-7D20C5DE-5129-4D43-AAF2-348F5C26414FQ39542449-4625E0B9-33E8-4D07-8FC9-76DED9DB01CEQ39625852-ADA1D018-D8E1-402E-9AC1-3BD16C69DBA3Q39771581-1C233FFB-9327-4A92-A623-88F0DDB9BE23Q39871177-FF057678-C3F8-400B-B70C-534A40067E61Q40136247-D91053FC-D24F-458D-96E7-9C145E13E25BQ42653467-055B3627-B84D-4B3E-B47A-DAB9ACECFE61Q42878172-1238BEC2-5191-430F-8450-D5F48911994EQ42953780-132443EF-B4CF-4BB5-87A6-B5A797DEE179Q45990590-117E43F7-8CFB-4ECA-9EA8-7BE7BA4BB239Q46938009-5EC8E897-59CF-4337-B82C-BCE42CAA90A2Q46968784-100FFFA4-4DE5-4032-B8ED-30D0C55B3115Q47628268-9A3E412A-F794-46FC-AC77-78D55BDC60E7Q47790954-F3D4ACD6-156B-49E6-B0A9-51737E8A9E0BQ48096907-E9AD18B3-66E7-473E-950D-F72FBA251B25Q48269821-63361783-529A-4838-BD5E-B071B28BE280Q50027324-B8CB008A-E1D7-49A6-88A1-86D2DA50D2ADQ54349828-E021E20E-8743-487B-81FB-532CA508C0A6Q55456818-E7B4785E-4B32-4DED-AD4F-B41AE6668DE9
P2860
CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@ast
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@en
type
label
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@ast
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@en
prefLabel
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@ast
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@en
P2093
P356
P1476
CYP3A4 induction by xenobiotic ...... rug discovery and development.
@en
P2093
Liang-Shang Gan
Thomas Guenthner
W Griffith Humphreys
P304
P356
10.2174/1389200043335397
P407
P577
2004-12-01T00:00:00Z