A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4
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Mouse transgenesis in a single locus with independent regulation for multiple fluorophoresEffects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice.Pregnane X receptor and drug-induced liver injury.Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.Expression and regulation of human fetal-specific CYP3A7 in miceSmall-molecule modulators of PXR and CAR.PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicityLong-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Orphan nuclear receptors as targets for drug development.Challenges and opportunities of metabolomics.Xenobiotic receptor humanized mice and their utility.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Novel pre-clinical methodologies for pharmacokinetic drug-drug interaction studies: spotlight on "humanized" animal models.Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.Rifampin-Mediated Induction of Tamoxifen Metabolism in a Humanized PXR-CAR-CYP3A4/3A7-CYP2D6 Mouse Model.Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay
P2860
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P2860
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 17 September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A double transgenic mouse mode ...... ceptor and cytochrome P450 3A4
@en
A double transgenic mouse mode ...... eptor and cytochrome P450 3A4.
@nl
type
label
A double transgenic mouse mode ...... ceptor and cytochrome P450 3A4
@en
A double transgenic mouse mode ...... eptor and cytochrome P450 3A4.
@nl
prefLabel
A double transgenic mouse mode ...... ceptor and cytochrome P450 3A4
@en
A double transgenic mouse mode ...... eptor and cytochrome P450 3A4.
@nl
P2093
P2860
P356
P1476
A double transgenic mouse mode ...... ceptor and cytochrome P450 3A4
@en
P2093
Connie Cheung
Frank J Gonzalez
Jeffrey R Idle
Kristopher W Krausz
Xiaochao Ma
Yatrik M Shah
P2860
P304
P356
10.1124/DMD.108.022723
P577
2008-09-17T00:00:00Z