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Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinicMDA-7/IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosisA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosisMelanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector.Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cellsEradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24BI-69A11 enhances susceptibility of colon cancer cells to mda-7/IL-24-induced growth inhibition by targeting AktMDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant gliomaPERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.Tumour suppressor function of MDA-7/IL-24 in human breast cancerIL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.The development of MDA-7/IL-24 as a cancer therapeuticTRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cellsA serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Gene Therapies for Cancer: Strategies, Challenges and Successes.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineStrategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomasMDA-7/IL-24: multifunctional cancer killing cytokineIonizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic miceMelanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells.IL-24: a classic cytokine and/or a potential cure for cancer?Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.Suppression effect of recombinant adenovirus vector containing hIL-24 on Hep-2 laryngeal carcinoma cells.Interleukin and interleukin receptor diversity: role of alternative splicing.Oncolytic adenoviruses expressing interleukin: a novel antitumour approach.Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities.mda-7/IL-24 Mediates Cancer Cell-Specific Death via Regulation of miR-221 and the Beclin-1 Axis.Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
mda-7/IL-24: exploiting cancer's Achilles' heel.
@ast
mda-7/IL-24: exploiting cancer's Achilles' heel.
@en
type
label
mda-7/IL-24: exploiting cancer's Achilles' heel.
@ast
mda-7/IL-24: exploiting cancer's Achilles' heel.
@en
prefLabel
mda-7/IL-24: exploiting cancer's Achilles' heel.
@ast
mda-7/IL-24: exploiting cancer's Achilles' heel.
@en
P2093
P1433
P1476
mda-7/IL-24: exploiting cancer's Achilles' heel.
@en
P2093
Adly Yacoub
Casey Cunningham
Devanand Sarkar
Irina V Lebedeva
John Nemunaitis
Moira Sauane
Pankaj Gupta
Paul B Fisher
Rahul V Gopalkrishnan
Zhao-Zhong Su
P356
10.1016/J.YMTHE.2004.08.012
P50
P577
2005-01-01T00:00:00Z