Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis. - Wikidata - awgldk - TriplyDB

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

http://www.wikidata.org/entity/Q36775413

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Mechanism of Action and Applications of Interleukin 24 in Immunotherapy Targeting Mcl-1 for the therapy of cancer Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.Cisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cells Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24 Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant glioma The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.MDA-7/IL-24 as a cancer therapeutic: from bench to bedside.Embryonic stem cell (ESC)-mediated transgene delivery induces growth suppression, apoptosis and radiosensitization, and overcomes temozolomide resistance in malignant gliomas.The development of MDA-7/IL-24 as a cancer therapeutic Recombinant adenovirus IL-24-Bax promotes apoptosis of hepatocellular carcinoma cells in vitro and in vivo.A first-generation multi-functional cytokine for simultaneous optical tracking and tumor therapy A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Reversing translational suppression and induction of toxicity in pancreatic cancer cells using a chemoprevention gene therapy approach Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV).Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24.Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.Gene Therapies for Cancer: Strategies, Challenges and Successes.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.Mechanism by which Mcl-1 regulates cancer-specific apoptosis triggered by mda-7/IL-24, an IL-10-related cytokine Biomarkers: the useful and the not so useful--an assessment of molecular prognostic markers for cutaneous melanoma mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.MDA-7/IL-24: multifunctional cancer killing cytokine Construction of expressing vectors including melanoma differentiation-associated gene-7 (mda-7) fused with the RGD sequences for better tumor targeting MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer.Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells.Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells.Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells Clinical applications of mouse models for breast cancer engaging HER2/neu.mda-7/IL-24 Mediates Cancer Cell-Specific Death via Regulation of miR-221 and the Beclin-1 Axis.Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis.MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis.IL-24 sensitizes tumor cells to TLR3-mediated apoptosis The novel compound OSI-461 induces apoptosis and growth arrest in human acute myeloid leukemia cells.

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Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

http://www.wikidata.org/entity/Q36775413

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@ast

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

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type

label

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@ast

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@en

prefLabel

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@ast

Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@en

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Proceedings of the National Academy of Sciences of the United States of America

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Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis.

@en

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Devanand Sarkar

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Irina V Lebedeva

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Moira Sauane

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Pankaj Gupta

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Paul B Fisher

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Zao-Zhong Su

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P2860

Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc

Intracellular signaling by the unfolded protein response

Interleukin-10 and related cytokines and receptors

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways

Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells

Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types

AP-1 and C/EBP transcription factors contribute to mda-7 gene promoter activity during human melanoma differentiation.

Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.

mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.

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105

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2008-07-03T00:00:00Z

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5252859

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18599461

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2474541

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