14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
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COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun ProteinLoss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway.Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer.Limiting the power of p53 through the ubiquitin proteasome pathway.CSN6 deregulation impairs genome integrity in a COP1-dependent pathwayThe cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogrammingMiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN.Aurora B kinase phosphorylates and instigates degradation of p53Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.The pineal gland: A model for adrenergic modulation of ubiquitin ligasesCOP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors.Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cellsEssential Roles of E3 Ubiquitin Ligases in p53 Regulation.Spotlight on the role of COP1 in tumorigenesis.New Insights into the Protein Turnover Regulation in Ethylene Biosynthesis.Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin.14-3-3σ downregulation suppresses ICC metastasis via impairing migration, invasion, and anoikis resistance of ICC cells.High level of COP1 expression is associated with poor prognosis in primary gastric cancer.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53.14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2.Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3.The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.
P2860
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P2860
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@ast
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@en
type
label
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@ast
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@en
prefLabel
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@ast
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.
@en
P2093
P2860
P1433
P1476
14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability
@en
P2093
Changju Qu
Chun-Hui Su
Fanmao Zhang
Huamin Wang
Ruiying Zhao
Sai-Ching J Yeung
P2860
P304
P356
10.1158/0008-5472.CAN-10-2518
P407
P577
2010-12-06T00:00:00Z