Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
about
Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways.Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer.Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.Signaling pathways as therapeutic targets in biliary tract cancer.Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis.Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling.Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer.
P2860
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P2860
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Rational combination of MEK in ...... reatic and colon cancer cells.
@ast
Rational combination of MEK in ...... reatic and colon cancer cells.
@en
type
label
Rational combination of MEK in ...... reatic and colon cancer cells.
@ast
Rational combination of MEK in ...... reatic and colon cancer cells.
@en
prefLabel
Rational combination of MEK in ...... reatic and colon cancer cells.
@ast
Rational combination of MEK in ...... reatic and colon cancer cells.
@en
P2093
P2860
P356
P1433
P1476
Rational combination of MEK in ...... reatic and colon cancer cells.
@en
P2093
Chengguang Zhao
Chenglong Li
Guang Liang
Jiayuh Lin
Shulin Yang
Xiaojuan Wu
P2860
P304
14472-14487
P356
10.18632/ONCOTARGET.3991
P407
P577
2015-06-01T00:00:00Z