New and old functions of STAT3: a pivotal target for individualized treatment of cancer
about
Crif1 is a novel transcriptional coactivator of STAT3Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylationCancer Stem Cell Hierarchy in Glioblastoma MultiformeSTAT3: A Novel Molecular Mediator of Resistance to ChemoradiotherapyDifferential Protein Distribution between the Nucleus and Mitochondria: Implications in AgingEriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphomaInhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer.Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase.Small molecule inhibitors of histone acetyltransferase Tip60Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver diseaseIdentification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma.Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.STAT3: a multifaceted oncogene.Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1βIdentification and saturable nature of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo, and in vitro administration.Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.NF-κB and STAT3 - key players in liver inflammation and cancerAntitumorigenic potential of STAT3 alternative splicing modulationA small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells.A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferationRational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer.Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotypeA combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemiaA novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells.Cancer Stem Cells in Glioblastoma Multiforme.Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.Inteferons pen the JAK-STAT pathway.Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer.Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer.The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer.Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.
P2860
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P2860
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@ast
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@en
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@nl
type
label
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@ast
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@en
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@nl
prefLabel
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@ast
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@en
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@nl
P2093
P3181
P356
P1433
P1476
New and old functions of STAT3: a pivotal target for individualized treatment of cancer
@en
P2093
David E Levy
Giorgio Inghirami
Karni Schlessinger
Roberto Chiarle
Roberto Piva
William J Simmons
P304
P3181
P356
10.4161/CC.4.9.1985
P407
P577
2005-09-01T00:00:00Z