A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
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Biology of the major facilitative folate transporters SLC19A1 and SLC46A1The proton-coupled folate transporter: physiological and pharmacological roles.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Delineating the extracellular water-accessible surface of the proton-coupled folate transporter.The intestinal absorption of folates.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Experimentally optimized threading structures of the proton-coupled folate transporter.The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860
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P2860
A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A P425R mutation of the proton ...... alteration in folate binding.
@ast
A P425R mutation of the proton ...... alteration in folate binding.
@en
type
label
A P425R mutation of the proton ...... alteration in folate binding.
@ast
A P425R mutation of the proton ...... alteration in folate binding.
@en
prefLabel
A P425R mutation of the proton ...... alteration in folate binding.
@ast
A P425R mutation of the proton ...... alteration in folate binding.
@en
P2093
P2860
P1476
A P425R mutation of the proton ...... alteration in folate binding.
@en
P2093
Daniel Sanghoon Shin
Enghui H Yap
I David Goldman
Rongbao Zhao
P2860
P304
P356
10.1152/AJPCELL.00435.2011
P50
P577
2012-02-15T00:00:00Z