The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.
about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Role of solute carriers in response to anticancer drugsBiological and Structural Evaluation of 10 R - and 10 S -Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide TransformylaseSubstituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The Concise Guide to PHARMACOLOGY 2013/14: transporters.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.The proton-coupled folate transporter: physiological and pharmacological roles.Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterThe intestinal absorption of folates.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Determinants of the activities of antifolates delivered into cells by folate-receptor-mediated endocytosis.Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).Targeted delivery of platinum-taxane combination therapy in ovarian cancer.6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adultsRole of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.The membrane transport and polyglutamation of pralatrexate: a new-generation dihydrofolate reductase inhibitorTumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyTumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer ChemotherapeuticsRole of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications.Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.Nanogels: An overview of properties, biomedical applications and obstacles to clinical translationDual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.Experimentally optimized threading structures of the proton-coupled folate transporter.Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation.A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer.mTOR folate sensing links folate availability to trophoblast cell function.Hereditary folate malabsorption with a novel mutation on SLC46A1: A case report.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860
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P2860
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The human proton-coupled folat ...... peutic applications to cancer.
@ast
The human proton-coupled folat ...... peutic applications to cancer.
@en
The human proton-coupled folat ...... peutic applications to cancer.
@nl
type
label
The human proton-coupled folat ...... peutic applications to cancer.
@ast
The human proton-coupled folat ...... peutic applications to cancer.
@en
The human proton-coupled folat ...... peutic applications to cancer.
@nl
prefLabel
The human proton-coupled folat ...... peutic applications to cancer.
@ast
The human proton-coupled folat ...... peutic applications to cancer.
@en
The human proton-coupled folat ...... peutic applications to cancer.
@nl
P2093
P2860
P921
P356
P1476
The human proton-coupled folat ...... peutic applications to cancer.
@en
P2093
Aleem Gangjee
Larry H Matherly
Sita Kugel Desmoulin
Zhanjun Hou
P2860
P304
P356
10.4161/CBT.22020
P5008
P577
2012-09-06T00:00:00Z
2012-12-01T00:00:00Z