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Old cells, new tricks: chromatin structure in senescenceBreaching the nuclear envelope in development and diseaseAging and longevity in the simplest animals and the quest for immortalityNuclear lamins and oxidative stress in cell proliferation and longevityOf flies, mice, and men: evolutionarily conserved tissue damage responses and agingCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear EdgeThe hallmarks of agingAutophagy mediates degradation of nuclear laminaLysosome-mediated processing of chromatin in senescence.Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescenceExpression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging.Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesisLoss of lamin B1 results in prolongation of S phase and decondensation of chromosome territoriesThe role of senescent cells in ageing.Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts.Aging, cellular senescence, and cancerAn essential role for senescent cells in optimal wound healing through secretion of PDGF-AAThree-dimensional genome architecture: players and mechanisms.Progerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation.Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation.Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia.Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.Are there roles for brain cell senescence in aging and neurodegenerative disorders?Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.Mitochondrial effectors of cellular senescence: beyond the free radical theory of agingInhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescenceRole of lamin b1 in chromatin instabilityIn vivo and in vitro analysis of age-associated changes and somatic cellular senescence in renal epithelial cells.Embryonic expression of the common progeroid lamin A splice mutation arrests postnatal skin developmentReplicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sitesAltered Protein Expression in the Ileum of Mice Associated with the Development of Chronic Infections with Echinostoma caproni (Trematoda).Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria.Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling.Unfolding the story of chromatin organization in senescent cells.The role of lamin B1 for the maintenance of nuclear structure and function.Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells.A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus.
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Lamin B1 loss is a senescence-associated biomarker.
@ast
Lamin B1 loss is a senescence-associated biomarker.
@en
type
label
Lamin B1 loss is a senescence-associated biomarker.
@ast
Lamin B1 loss is a senescence-associated biomarker.
@en
prefLabel
Lamin B1 loss is a senescence-associated biomarker.
@ast
Lamin B1 loss is a senescence-associated biomarker.
@en
P2093
P2860
P356
P1476
Lamin B1 loss is a senescence-associated biomarker
@en
P2093
Adam Freund
Judith Campisi
Remi-Martin Laberge
P2860
P304
P356
10.1091/MBC.E11-10-0884
P577
2012-04-11T00:00:00Z