AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewIntegration of troponin I phosphorylation with cardiac regulatory networksMyofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and RelaxationLength-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylationSexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy miceCombined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment.Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations.Top-down mass spectrometry of cardiac myofilament proteins in health and disease.Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mappingLKB1/Mo25/STRAD uniquely impacts sarcomeric contractile function and posttranslational modification.Left ventricular deformation associated with cardiomyocyte Ca(2+) transients delay in early stage of low-dose of STZ and high-fat diet induced type 2 diabetic rats.AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human HeartRapid large-scale purification of myofilament proteins using a cleavable His6-tag.Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.Molecule specific effects of PKA-mediated phosphorylation on rat isolated heart and cardiac myofibrillar functionLiver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytesThe β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calciumThe Modulation of Cardiac Contractile Function by the Pharmacological and Toxicological Effects of Urocortin2.Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation.Pathomechanisms in heart failure: the contractile connection.Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics.Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility.Designing proteins to combat disease: Cardiac troponin C as an example.Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation.Should we treat heart failure with phosphatase inhibitors? Better to start at the end.Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties.Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.Secondary phosphorylation in myocytes expressing FLAG-tagged and non-tagged phospho-mimetic cardiac troponin I.The art of the deal in myofilament modulation of function.The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform.Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24.
P2860
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P2860
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@ast
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@en
type
label
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@ast
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@en
prefLabel
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@ast
AMP-activated protein kinase p ...... blunt PKA-dependent function.
@en
P2093
P2860
P356
P1476
AMP-activated protein kinase p ...... d blunt PKA-dependent function
@en
P2093
Ariyoporn Thawornkaiwong
Brandon J Biesiadecki
Elizabeth A Brundage
Jonathan P Davis
R John Solaro
Sean C Little
P2860
P304
19136-19147
P356
10.1074/JBC.M111.323048
P407
P577
2012-04-06T00:00:00Z