The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium
about
The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivoDivergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)G protein-coupled receptors in cardiac biology: old and new receptorsAngiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery.Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.Discovery of GPCR ligands for probing signal transduction pathways.Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis.Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonistComparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.New paradigms in GPCR drug discovery.β-Arrestin mediates the Frank-Starling mechanism of cardiac contractilityMaladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death.Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.Recent developments in biased agonism.Neuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors.AT1 receptor signaling pathways in the cardiovascular system.A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors.Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice.Calcium in Brugada Syndrome: Questions for Future ResearchDesigner Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease
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The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The β-arrestin-biased ligand T ...... yofilament response to calcium
@en
The β-arrestin-biased ligand T ...... ofilament response to calcium.
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type
label
The β-arrestin-biased ligand T ...... yofilament response to calcium
@en
The β-arrestin-biased ligand T ...... ofilament response to calcium.
@nl
prefLabel
The β-arrestin-biased ligand T ...... yofilament response to calcium
@en
The β-arrestin-biased ligand T ...... ofilament response to calcium.
@nl
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The β-arrestin-biased ligand T ...... yofilament response to calcium
@en
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Chad M Warren
David G Soergel
Domenico M Taglieri
Jonathan D Violin
Marcus Henze
Megan S Utter
Michelle M Monasky
R John Solaro
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P304
P356
10.1152/AJPHEART.00327.2013
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2013-07-19T00:00:00Z