Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons - Wikidata - awgldk - TriplyDB

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons

http://www.wikidata.org/entity/Q36016964

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Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium.Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin Zinc and the aging brain Disruption of zinc homeostasis and the pathogenesis of senile dementia.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides.Zinc, Carnosine, and Neurodegenerative Diseases.Metal Ion Effects on Aβ and Tau Aggregation.Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.Implications of Metal Binding and Asparagine Deamidation for Amyloid Formation

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P2860

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons

http://www.wikidata.org/entity/Q36016964

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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name

Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Journal of Biological Chemistry

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Zn2+-Aβ40 complexes form metas ...... o cultured hippocampal neurons

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Arkady Bitler

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Benjamin Born

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Eduard Korkotian

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Farid Rahimi

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Gal Bitan

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Huiyuan Li

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Inna Solomonov

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Irit Sagi

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Yishay Feldman

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P2860

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders

Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Alzheimer's amyloid fibrils: structure and assembly.

Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.

A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events.

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22528492

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