Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
about
NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's diseaseGenetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathwaysThermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approachesCation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic DomainBacterial Magnetosome Biomineralization - A Novel Platform to Study Molecular Mechanisms of Human CDF-Related Type-II DiabetesAmyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assembliesMechanics of metal-catecholate complexes: the roles of coordination state and metal types.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH.Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.Amyloid peptide Aβ40 inhibits aggregation of Aβ42: evidence from molecular dynamics simulations.Alzheimer's disease: which type of amyloid-preventing drug agents to employ?Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Oligomerization of a retroviral matrix protein is facilitated by backbone flexibility on nanosecond time scaleMolecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.Conformational stability of fibrillar amyloid-beta oligomers via protofilament pair formation - a systematic computational studyMolecular dynamics study of Zn(aβ) and Zn(aβ)2Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states.Role of metal dyshomeostasis in Alzheimer's disease.Systematic examination of polymorphism in amyloid fibrils by molecular-dynamics simulation.Substantial contribution of the two imidazole rings of the His13-His14 dyad to Cu(II) binding in amyloid-β(1-16) at physiological pH and its significance.Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation.Zn-responsive proteome profiling and time-dependent expression of proteins regulated by MTF-1 in A549 cellsAmyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation.Environmental factors preceding aβ40 monomer to oligomers and the detection of oligomers in Alzheimer's disease patient serumIntracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice.Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neuronsStudies on the interactions of copper and zinc ions with β-amyloid peptides by a surface plasmon resonance biosensor.Allosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal.Structures and free energy landscapes of aqueous zinc(II)-bound amyloid-β(1-40) and zinc(II)-bound amyloid-β(1-42) with dynamics.Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity.Transition metal homeostasis: from yeast to human disease.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.The role of metallobiology and amyloid-β peptides in Alzheimer's disease.Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease.Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Beta-amyloid oligomers: recent developments.
P2860
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P2860
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@ast
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@en
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@nl
type
label
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@ast
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@en
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@nl
prefLabel
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@ast
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@en
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@nl
P2860
P356
P1476
Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states.
@en
P2093
Yifat Miller
P2860
P304
P356
10.1073/PNAS.0913114107
P407
P577
2010-05-06T00:00:00Z