Ivermectin reduces alcohol intake and preference in mice.
about
P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersRecent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorinContribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humansA mouse line for inducible and reversible silencing of specific neuronsAvermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.Oral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder.Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) RatsRodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals.A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder.P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate NucleusSeeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models.Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin.Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.P2X4: A fast and sensitive purinergic receptor.Medications for alcohol use disorders: An overview.Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.
P2860
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P2860
Ivermectin reduces alcohol intake and preference in mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Ivermectin reduces alcohol intake and preference in mice.
@ast
Ivermectin reduces alcohol intake and preference in mice.
@en
type
label
Ivermectin reduces alcohol intake and preference in mice.
@ast
Ivermectin reduces alcohol intake and preference in mice.
@en
prefLabel
Ivermectin reduces alcohol intake and preference in mice.
@ast
Ivermectin reduces alcohol intake and preference in mice.
@en
P2093
P2860
P50
P1433
P1476
Ivermectin reduces alcohol intake and preference in mice
@en
P2093
Deborah A Finn
Liana Asatryan
Megan M Yardley
Nhat Huynh
Ronald L Alkana
Sheraz Khoja
Stan G Louie
P2860
P304
P356
10.1016/J.NEUROPHARM.2012.03.014
P577
2012-03-23T00:00:00Z